Prevalência do uso de medicamentos de risco durante a gravidez e lactação em unidades básicas de saúde do Distrito Federal

O uso de medicamentos durante as fases da gestação e lactação é um assunto de extremarelevância, uma vez que, a escassez de pesquisas com esses grupos torna difícil o acesso aosdados sobre os possíveis efeitos e riscos dos fármacos. O objetivo do atual estudo buscaanalisar a utilização de medicamentos em gestantes e lactantes atendidas nas UnidadesBásicas de Saúde da região central do Distrito Federal e classificar o risco de tais fármacossegundo a Food and Drug Administration. Nesta pesquisa foi realizada a coleta de dados pormeio de um questionário pelo Google Forms. A pesquisa ocorreu entre agosto de 2020 ejulho de 2021, por meio de análise bibliográfica e de coleta de dados do questionário. Osresultados mostraram que as mulheres 34% eram lactantes e 66% gestantes e 100% tiveramalguma prescrição médica, incluindo ácido fólico, sulfato ferroso e polivitamínicos. O índicede automedicação foi alto, 22%, sendo os analgésicos, antipiréticos e antieméticos as classesterapêuticas mais utilizadas. O uso de fármacos por estas mulheres foi predominante noprimeiro trimestre, sendo seguido pelo segundo e pelo terceiro, sendo que as mesmasestavam sendo acompanhadas por assistência médica. Diante desses resultados concluímosque os profissionais da saúde foram cautelosos ao receitar os medicamentos demonstrandouma prescrição racional. Entretanto destaca-se a relevância na produção de campanhaspelas Unidades Básicas alertando e orientando os profissionais da área para que atente-sequanto ao cuidado nas prescrições medicamentosas, bem como as mulheres deste gruposobre os possíveis efeitos, além de enfatizar sobre os riscos da automedicação. Desta formaevitaremos erros de prescrição e, consequentemente danos à saúde da gestante, feto ecriança

Prosodic, syntactic, semantic guidelines for topic structures across domains and corpora

This paper presents the annotation guidelines applied to naturally occurring speech, aiming at an integrated account of contrast and parallel structures in European Portuguese. These guidelines were defined to allow for the empirical study of interactions among intonation and syntax-discourse patterns in selected sets of different corpora (monologues and dialogues, by adults and teenagers). In this paper we focus on the multilayer annotation process of left periphery structures by using a small sample of highly spontaneous speech in which the distinct types of topic structures are displayed. The analysis of this sample provides fundamental training andtesting material for further application in a wider range of domains and corpora. The annotation process comprises the following time-linked levels (manual and automatic): phone, syllable and word level transcriptions (including co-articulation effects); tonal events and break levels; part-of-speech tagging; syntactic-discourse patterns (construction type; construction position; syntactic function; discourse function), and disfluency events as well. Speech corpora with such a multi-level annotation are a valuable resource to look into grammar module relations in language use from an integrated viewpoint. Such viewpoint is innovative in our language, and has not been often assumed by studies for other languages

COFFEE: A HEALTH FUEL-BLOT POPULAR DRINKING

Now, the days begin with cups of coffee worldwide. Caffeine is the main component of coffee, which is vastly consumed as a psychoactive agent, and in varieties of dietary supplements. Day by day coffee and caffeinated-consumption areas are expanding. Only a single cup of coffee contains thousands of biochemical. Otherwise, during roasting, some of which turn to convert other chemicals moieties. Thus, the coffee is an interesting item to the drug scientists. Upon this jackpot, a number of researches have been done on coffee and its chemical components; in which many postulations are still in contentious and some are unclear to the coffee users. Upon going through the stand-point, this study has been snapshot to sketch a complete overview on coffee and its components. Our finding depicts constituents of coffee to have antioxidant, anti-inflammatory, anti-Alzheimer's disease, anti-Parkinson's disease, and cardioprotective activities. But the anti-cancerous effect of coffee components is not clear yet. In conclusion, coffee, and its constituents are in important in phytopharmacological research.Keywords: Coffee, Coffee components, Health-effect

Possible oxidative effects of isotretinoin and modulatory effects of vitamins A and C in Saccharomyces cerevisiae

Isotretinoin (ITN), chemically known as 13-cis-retinoic acid, is a part of the broad group of compounds related to vitamin A. It is particularly employed in the treatment of nodular cystic acne and as an inhibitor of proliferation of neoplastic cells, by exerting a regulatory effect on the cell differentiation. This study aimed at investigating the possible oxidative effects of ITN and modulatory effects of vitamins A and C in mutant and non-mutant Saccharomyces cerevisiae strains. In addition, to reconfirm the oxidative effects, five in vitro antioxidant assays were also prepared taking the alpha-tocopherol analogue, trolox as a standard. In vivo study conducted on S. cerevisiae cells was carried out with ITN 20 μg/ml taking hydrogen peroxide (H2O2) as stressor (STR), whereas ITN 5 to 50 μg/ml was considered for in vitro assays taking similar dose of trolox (TRO). Results show ITN to have oxidative effect in both in vitro and in vivo tests. In conclusion, ITN produced oxidative effects and there may be an hypervitaminosis effect with vitamins A and C, thus insinuation to genetic material.Key words: Assay, isotretinoin, vitamin A, vitamin C, oxidative stress

Oficinas de Parentalidade

Este artigo apresenta o projeto de extensão “Oficinas de Parentalidade”, desenvolvido na Universidade Federal do Triângulo Mineiro em parceria com a 8 ª Promotoria de Justiça de Uberaba”“MG, a partir da Recomendação 050/2014 do Conselho Nacional de Justiça. O objetivo do projeto é atender famílias em processo de divórcio e/ou dissolução da união estável, com um viés pedagógico e não terapêutico. Transmitindo técnicas apropriadas de comunicação na família, ensinamentos a respeito das consequências que os conflitos proporcionam aos filhos e informações legais sobre alienação parental, guarda, visitas e alimentos, busca-se auxiliar os pais e os filhos (adolescentes e crianças) no enfrentamento desses processos e suas consequências. São realizadas quatro oficinas mensais para filhos e pais, separadamente, em um único encontro de 4 horas de duração: uma para crianças de 6 a 11 anos, outra para adolescentes de 12 a 17 anos e duas para os pais, sendo que o ex-casal é alocado em salas diferentes, porém mistas. Cada oficina é coordenada por dois instrutores previamente capacitados e o material utilizado é cedido pelo Conselho Nacional de Justiça (CNJ). Espera-se que tais intervenções possam reduzir e/ou minimizar os traumas decorrentes das mudanças das relações familiares e comunicações conflituosas

MENOPAUSA E CÂNCER DE MAMA: RISCOS E PREVENÇÃO

The menopause is a natural period in women's lives, marked by the cessation of menstruation and significant hormonal changes. However, this stage is also associated with an increased risk of breast cancer. This study aims to analyze the risk factors for breast cancer during the menopause and propose effective prevention measures. To achieve this objective, a systematic review of the literature was carried out, including epidemiological studies, clinical trials and recent reviews. Data related to age at menopause, hormone therapy, family history and lifestyle habits were analyzed. In addition, prevention strategies were identified, such as weight control, regular physical activity, healthy eating and mammography screening. The menopause is a critical period for women's health, with increased risks of breast cancer due to hormonal changes. However, awareness and the adoption of preventive measures can significantly reduce this risk. Weight control, physical activity and a balanced diet play essential roles in prevention. In addition, regular mammographic screening in women in the appropriate age group is essential for the early detection of breast cancer.A menopausa é um período natural na vida das mulheres, marcado pela cessação da menstruação e mudanças hormonais significativas. No entanto, esse estágio também está associado a um aumento do risco de câncer de mama. Este estudo tem como objetivo analisar os fatores de risco do câncer de mama durante a menopausa e propor medidas de prevenção eficazes. Para alcançar esse objetivo, realizou-se uma revisão sistemática da literatura, incluindo estudos epidemiológicos, ensaios clínicos e revisões recentes. Foram analisados dados relacionados à idade da menopausa, terapia hormonal, histórico familiar e hábitos de vida. Além disso, foram identificadas estratégias de prevenção, como o controle de peso, atividade física regular, alimentação saudável e rastreamento mamográfico. A menopausa é um período crítico para a saúde da mulher, com riscos aumentados de câncer de mama devido às mudanças hormonais. No entanto, a conscientização e a adoção de medidas preventivas podem reduzir significativamente esse risco. O controle do peso, a prática de atividades físicas e uma dieta equilibrada desempenham papéis essenciais na prevenção. Além disso, o rastreamento mamográfico regular em mulheres na faixa etária apropriada é fundamental para a detecção precoce do câncer de mama

Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients- A Clinical Perspective Study

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. Therefore, the objective of this study was to analyze correlation between sociocultural, occupational, and lifestyle risk factors with levels of genetic instability in non-neoplastic cells of breast cancer patients. Total 150 individuals were included in the study that included 50 breast cancer patients submitted to chemotherapy (QT), 50 breast cancer patients submitted to radiotherapy (RT), and 50 healthy women without any cancer. Cytogenetic biomarkers for apoptosis and DNA damage were evaluated in samples of buccal epithelial and peripheral blood cells through micronuclei and comet assay tests. Elder age patients (61–80 years) had higher levels of apoptosis (catriolysis by karyolysis) and DNA damage at the diagnosis (baseline damage) with increased cell damage during QT and especially during RT. We also reported the increased frequencies of cytogenetic biomarkers in patients who were exposed to ionizing radiation as well as for alcoholism and smoking. QT and RT induced high levels of fragmentation (karyorrhexis) and nuclear dissolution (karyolysis) and DNA damage. Correlations were observed between age and karyorrhexis at diagnosis; smoking and karyolysis during RT; and radiation and karyolysis during QT. These correlations indicate that risk factors may also influence the genetic instability in non-neoplastic cells caused to the patients during cancer therapies

Multidimensional assessment of institutionalized elderly: the reality of a brazilian institution

Background: The population aging in Brazil is characterized by the accumulation of progressive disabilities in their functional activities and daily life. To consider the elderlies in his/her multiple dimensions turns out to be a critical issue to improvetheir assistance to an institu-tionalized level, improving their health and quality of life. To perform a mini-overall evaluation of institutionalized elderly person to trace their profile in relation to the socio-demographic, functional capacity, nutritional status and cognition. Methods: Descriptive study, with a cross-sectional design and quan-titative approach performed in a long - stay institution for the elderly in Natal, RN. The research was approved by the Research Ethics Com-mittee of the Federal University of Rio Grande do Norte, under opinion number 164/2011.Results: 63.3% of the elderly were female, with ages varying from 61 to 103 years. 60.0% were single; 56.7% were literate. 66.7% had no children and 55% lived with their families before the institutio-nalization. As for the institutionalization time, 63.3% resided in the institution for four years. As what concerns the aspects of health, 73.3% of the elderly presented hearing difficulties, 90% make use of medicines predominantly to diabetes and hypertension. There is clear evidence that the institutionalization has been harmful to the elderly as with regards basic activities of daily living, nutritional status and cognitive aspects. Conclusion: The progressive disability in functional activities of daily life interferes directly in the quality of life, increasing dependency and minimizing the autonomy of these individuals. It is necessary to effec-tive implementation of public policies directed to the institutionalized elderly from the perspective of effective actions for improved attention and assistance

Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa

© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (May 2018) in accordance with the publisher’s archiving policyOmeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages. OME was tested at 10, 20 and 40 μg/mL, while RP and AA at 55 μg/mL and 352.2 μg/mL, respectively. Copper sulphate (0.6 μg/mL) and dechlorinated water were used as positive control and negative control, respectively. The results suggest that OME induced genotoxicity and mutagenicity in A. cepa at all tested concentrations. It was noted that cotreatment of OME with the antioxidant vitamins RP and/or AA significantly (p < 0.05) inhibited and/or modulated all toxicogenic damages induced by OME. These observations demonstrate their antigenotoxic, antimutagenic, antitoxic and anticitotoxic effects in A. cepa. This study indicates that application of antioxidants may be useful tools to overcome OME-induced toxic effects